Thrombomodulin
نویسندگان
چکیده
منابع مشابه
Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma.
Endothelial cell membrane-bound thrombomodulin (TM) plays a critical role as a cofactor in the protein C pathway, important in regulating coagulation as well as inflammation. Heterogeneous soluble TM fragments circulate in the plasma and are found at increased levels in various diseases such as cardiovascular disease and diabetes, and in ischemic and/or inflammatory endothelial injuries. The an...
متن کاملThrombomodulin and the brain
Neurology® 2012;78:1 In this issue of Neurology, Giwa et al.1 report robust expression of thrombomodulin (TM) in small vessel disease, i.e., in small brain arteries or arterioles that exhibit the typical hyalinized thickening characteristic of chronic hypertensive changes. Using immunohistochemistry of postmortem brain tissue, the authors demonstrate extensive presence of TM in these small arte...
متن کاملNeuroprotection by recombinant thrombomodulin.
We examined whether recombinant human soluble thrombomodulin (rhs-TM) reduces compression trauma-induced spinal cord injury through protein C activation in rats. Administration of rhs-TM, either before or after the induction of spinal cord injury (SCI), markedly reduced the resulting motor disturbances. However, neither rhs-TM pretreated with an anti-rhs-TM monoclonal antibody (MAb) F2H5, which...
متن کاملSerum Thrombomodulin after Lung Resection
135 Received June 1, 2012; accepted September 3, 2012. Published online September 14, 2012; doi: 10.1620/tjem.228.135. Correspondence: Sumiko Maeda, M.D., Ph.D., Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiryomachi, Aobaku, Sendai, Miyagi 980-8575, Japan. e-mail: [email protected] *Present address: Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiry...
متن کاملSoluble thrombomodulin protects ischemic kidneys.
Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal aortic blood flow and femoral arterial press...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2009
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.20.9